BOSTON, June 5: Stephen Quake, a prolific inventor whose creative application of physics to biology has lead to multiple developments in drug discovery and genome analysis, has won the prestigious $500,000 Lemelson-MIT prize for outstanding innovators. Quake, a professor of bioengineering and applied physics at Stanford University and investigator at the Howard Hughes Medical Institute, has applied the technological principles of the integrated circuit – a chip made of semiconductor material found in almost every modern electrical device – to biology. (agencies)