LOS ANGELES : Scientists have for the first time found that Zika triggers cell suicide in the developing brain, a finding that may explain how the virus causes babies to be born with abnormally small heads, and also help develop new therapies against the infection.
The US Centres for Disease Control and Prevention recently concluded that Zika virus infection in pregnant women can stunt neonatal brain development, leading to babies born with abnormally small heads, a condition known as microcephaly.
Now, researchers at University of California San Diego found one way Zika can damage developing brain cells.
They also found that inhibiting this mechanism reduces brain cell damage, hinting at a new therapeutic approach to mitigating the effects of prenatal Zika virus infection.
Using a 3D, stem cell-based model of a first-trimester brain, researchers found that Zika activates TLR3, a molecule human cells normally use to defend against invading viruses.
In turn, hyper-activated TLR3 turns off genes that stem cells need to specialise into brain cells and turns on genes that trigger cell suicide.
“We all have an innate immune system that evolved specifically to fight off viruses, but here the virus turns that very same defence mechanism against us,” said Tariq Rana, professor at UC San Diego.
“By activating TLR3, the Zika virus blocks genes that tell stem cells to develop into the various parts of the brain. The good news is that we have TLR3 inhibitors that can stop this from happening,” said Rana.
The researchers’ model closely resembled foetal brain tissue at eight to nine weeks post-conception. (AGENCIES)
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